COMPUTATION-BASED VIRTUAL SCREENING FOR DESIGNING NOVEL ANTIMALARIAL DRUGS BY TARGETING FALCIPAIN-III: A STRUCTURE-BASED DRUG DESIGNING APPROACH

Computation-based virtual screening for designing novel antimalarial drugs by targeting falcipain-III: A structure-based drug designing approach

Background & objectives: Cysteine proteases (falcipains), a papain-family of enzymes of Plasmodium falciparum, are responsible for haemoglobin degradation and thus necessary for its survival during asexual life cycle phase inside the human red blood cells while remaining non-functional for the human body.Therefore, these can act as potential target

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Detection, quantification and genotyping of Herpes Simplex Virus in cervicovaginal secretions by real-time PCR: a cross sectional survey

Abstract Background Herpes Simplex Virus (HSV) Genital Ulcer Disease (GUD) is an important public health problem, whose interaction with HIV results in mutually enhancing epidemics.Conventional methods for detecting HSV tend to be slow and insensitive.We designed a rapid PCR-based assay to quantify and styling type HSV in cervicovaginal lavage (CVL

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Economic evaluation in traditional and industrial livestock with different levels of milk production in ardebil province with emphasis on risk criteria

The main objective of the livestock industry, as an economic production system, is to increase production efficiency through changes in performance and to increase economic productivity.Therefore, in designing genetic improvement programs for domestic animals, it is necessary to pay attention to recognizing the system of production and the factors

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